Brendan Lee Selected Research

Ornithine Carbamoyltransferase (Ornithine Transcarbamylase)

9/2013	Vector sequences are not detected in tumor tissue from research subjects with ornithine transcarbamylase deficiency who previously received adenovirus gene transfer.
3/2009	High-frequency detection of deletions and variable rearrangements at the ornithine transcarbamylase (OTC) locus by oligonucleotide array CGH.
8/2008	Cross-sectional multicenter study of patients with urea cycle disorders in the United States.
9/2004	Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus.

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Brendan Lee Research Topics

Disease

20	Inborn Urea Cycle Disorders 03/2016 - 12/2002
18	Osteogenesis Imperfecta (Lobstein Disease) 01/2024 - 12/2006
14	Hyperammonemia 01/2020 - 10/2004
11	Argininosuccinic Aciduria 01/2023 - 10/2004
10	Neoplasms (Cancer) 10/2023 - 09/2005
8	Ornithine Carbamoyltransferase Deficiency Disease 09/2013 - 10/2003
7	Osteoporosis 10/2023 - 12/2006
5	Fibrosis (Cirrhosis) 01/2020 - 10/2004
4	Inflammation (Inflammations) 01/2023 - 05/2003
4	Inborn Genetic Diseases (Disease, Hereditary) 01/2023 - 10/2007
4	Muscle Hypotonia (Hypotonia) 01/2018 - 08/2002
4	Hypertension (High Blood Pressure) 10/2017 - 09/2009
3	Neoplasm Metastasis (Metastasis) 01/2021 - 02/2011
3	Hypertrophy 05/2015 - 12/2005
3	Hemophilia A (Haemophilia) 07/2012 - 12/2007
3	Hyperargininemia 02/2011 - 10/2004
2	Pain (Aches) 01/2024 - 01/2023
2	Breast Neoplasms (Breast Cancer) 10/2023 - 01/2021
2	Metabolic Bone Diseases (Osteopenia) 10/2023 - 12/2006
2	Seizures (Absence Seizure) 09/2023 - 01/2018
2	Lysinuric Protein Intolerance 01/2023 - 01/2020
2	Necrosis 01/2023 - 08/2014
2	Muscular Diseases (Myopathy) 01/2023 - 10/2012
2	Body Weight (Weight, Body) 01/2023 - 01/2022
2	Developmental Disabilities (Developmental Disability) 01/2022 - 01/2021
2	Liver Diseases (Liver Disease) 01/2020 - 09/2004
2	Osteosarcoma (Osteogenic Sarcoma) 01/2020 - 04/2009
2	Scoliosis 05/2019 - 12/2018
2	type 6 Osteogenesis imperfecta 07/2018 - 12/2011
2	Ataxia (Dyssynergia) 01/2018 - 01/2012
2	Disease Progression 09/2017 - 01/2017
2	Contracture 09/2014 - 03/2011
2	Citrullinemia 08/2008 - 03/2005
2	Cartilage-hair hypoplasia 10/2006 - 12/2005
2	Thrombocytopenia (Thrombopenia) 03/2005 - 02/2002
1	Acute Pain 01/2024
1	Prostatic Neoplasms (Prostate Cancer) 10/2023
1	Learning Disabilities (Learning Disability) 09/2023
1	Autism Spectrum Disorder 09/2023
1	Neurodevelopmental Disorders 09/2023
1	Immune System Diseases (Immune Disorders) 01/2023
1	Muscular Dystrophies (Muscular Dystrophy) 01/2023
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2023

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 09/2023 - 05/2002
15	NitrogenIBA 01/2020 - 12/2002
13	Urea (Carbamide)FDA LinkGeneric 01/2023 - 12/2002
11	EnzymesIBA 01/2022 - 02/2002
10	Collagen Type I (Type I Collagen)IBA 08/2023 - 12/2006
9	AmmoniaIBA 07/2015 - 12/2002
6	CollagenIBA 01/2021 - 05/2002
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023 - 09/2009
5	OrnithineIBA 01/2023 - 07/2006
5	glycerol phenylbutyrateIBA 03/2016 - 07/2010
5	Arginine (L-Arginine)FDA Link 11/2012 - 08/2008
4	Amino Acids FDA Link 01/2020 - 10/2005
4	ArginaseIBA 01/2018 - 10/2004
4	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 03/2007
4	Ornithine Carbamoyltransferase (Ornithine Transcarbamylase)IBA 09/2013 - 09/2004
4	4-phenylbutyric acid (Buphenyl)FDA Link 06/2013 - 07/2010
4	Argininosuccinic AcidIBA 06/2013 - 10/2004
3	Transcription Factors (Transcription Factor)IBA 09/2023 - 05/2002
3	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 05/2012
3	Teriparatide (Parathar)FDA Link 01/2021 - 02/2014
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2018
3	alpha2 Subunit Collagen Type IIBA 11/2020 - 12/2008
3	Glutamine (L-Glutamine)FDA Link 07/2015 - 10/2003
3	Messenger RNA (mRNA)IBA 08/2014 - 09/2005
3	CitrullineIBA 03/2009 - 03/2007
2	CytokinesIBA 01/2023 - 12/2005
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2023 - 11/2011
2	arginyllysineIBA 01/2023 - 01/2020
2	RNA (Ribonucleic Acid)IBA 01/2021 - 12/2005
2	Alanine Transaminase (SGPT)IBA 01/2020 - 03/2005
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 01/2018
2	Apolipoproteins E (ApoE)IBA 01/2020 - 03/2004
2	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2019 - 06/2014
2	Diphosphonates (Bisphosphonates)IBA 05/2019 - 12/2018
2	Protease Inhibitors (Protease Inhibitor)IBA 07/2018 - 12/2011
2	SerpinsIBA 07/2018 - 12/2011
2	pigment epithelium-derived factorIBA 07/2018 - 12/2011
2	Dietary ProteinsIBA 07/2015 - 02/2011
2	Antihypertensive Agents (Antihypertensives)IBA 05/2015 - 05/2012
2	Branched-Chain Amino AcidsIBA 02/2011 - 04/2004
2	phenylacetic acid (phenylacetate)FDA Link 02/2011 - 10/2008
2	Factor VIII (Coagulation Factor VIII)IBA 02/2011 - 12/2007
1	Opioid Analgesics (Opioids)IBA 01/2024
1	N-succinimidyl 8-((4'-fluorobenzyl)amino)suberateIBA 10/2023
1	Vitamin D FDA LinkGeneric 10/2023
1	Oxidoreductases (Dehydrogenase)IBA 01/2023
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2023
1	Mevalonic Acid (Mevalonate)IBA 01/2023
1	Inflammation MediatorsIBA 01/2023
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2023
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2023
1	Tartrate-Resistant Acid PhosphataseIBA 01/2023
1	Nerve Growth Factor (NGF)IBA 01/2023

Therapy/Procedure

18	Therapeutics 01/2023 - 04/2004
3	Liver Transplantation 05/2012 - 10/2004
2	Drug Therapy (Chemotherapy) 01/2020 - 12/2017
1	Pain Management 01/2024